Adeno-associated virus-mediated gene delivery
نویسندگان
چکیده
منابع مشابه
Adeno-associated virus vector-mediated IL-10 gene delivery prevents type 1 diabetes in NOD mice.
The development of spontaneous autoimmune diabetes in nonobese diabetic (NOD) mice provides for their use as a model of human type 1 diabetes. To test the feasibility of muscle-directed gene therapy to prevent type 1 diabetes, we developed recombinant adeno-associated virus (rAAV) vectors containing murine cDNAs for immunomodulatory cytokines IL-4 or IL-10. Skeletal muscle transduction of femal...
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Relatively successful elsewhere, gene delivery aimed at the vasculature and kidney has made very little progress. In the kidney, the hurdles are related to the unique structure-function relationships of this organ and in the blood vessels to a variety of, mostly endothelial, factors making the delivery of transgenes very difficult. Among gene-therapeutic approaches, most viral gene delivery sys...
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ژورنال
عنوان ژورنال: The Journal of Gene Medicine
سال: 1999
ISSN: 1099-498X,1521-2254
DOI: 10.1002/(sici)1521-2254(199905/06)1:3<166::aid-jgm34>3.0.co;2-z